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Previous studies have theoretically and experimentally demonstrated the positive therapeutic effects of modulating oxidation in viral CAPs, such as COVID-19, but there is a relative lack of more relevant clinical studies to further clarify the clinical efficacy in CAP infection caused by other pathogens

J Frailty Aging

IFN--activated macrophages reduce Cu levels in phagosomes to control the fungal pathogen Histoplamsa capsulatum (White et al., 2009a)

thaliana , overexpressed NRAMP6 resulted in Cd hypersensitivity through increased Cd uptake, while nramp6 loss of function mutants resulted in reduced Cd uptake leading to increased plant tolerance when exposed to high levels of Cd ( NRAMP5 resulted in reduced Cd accumulation in roots and leaves (Sasaki et al., 2012)

4.10 Lifestyle interventions and environmental factors in AT function AT plays a crucial role in regulating whole-body metabolism and energy homeostasis (250)

These findings suggest that loss of PDI functional activity can directly lead to apoptosis, or indirectly, to a range of cellular abnormalities, such as oxidative stress, protein misfolding, as well as cell death (Jeon et al., 2014)