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227,228 The comorbidities of MDD have attracted widespread attention, the intestinal gut microbial dysbiosis, liver dysfunction, immune system disorders all play important roles in the pathogenesis of MDD

Vi thnh phn Leucotomos sn phm em li kh nng chng nng v cng ti u, gip bo v ln da ch em trong sut 12h v o thi c t cho da bi tc ng t nh nng 12h sau m chng h thua km bt k dng chng nng no khc

Chem Biol, 2012

Chronic diseases are complex, stemming from the interplay of various pathological processes

Notably, the pyroptosis cascade further promotes NET formation: released IL-1 recruits more neutrophils to the injury site and upregulates PAD4 expression via the IL-1R/MyD88 signaling pathway, inducing histone citrullination