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This stage involved culturing DE cells in RPMI1640 medium supplemented with 1 B27

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Given what we do understand about the potential action on cellular signaling pathways this could pose serious risk

SASP (senescence-associated secretory phenotype) results revealed that FOXO4-DRI downregulates the levels of IL-1 , IL-6 , IL-8 , and TNF- (Figure 4H)