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Since there is no known hazardous threshold for vitamin B12, there is no upper limit

If you are always exhausted regardless of how much rest you get, that could mean that you are a good candidate for vitamin injections

But medically, dark brown urine could be an alert that the liver or kidneys are malfunctioning particularly if the patient also has pale stools and yellowing skin and eyes

Others need higher doses

You may have heard that you should avoid foods high in folate if you have an MTHFR mutation

Its sequence contains two cysteine residues that form a disulfide bridge, giving the fragment a constrained loop structure important for its activity