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Because occludin, ZO-1, ZO-2, and claudin-5 are phosphoproteins, any changes in phosphorylation may result in altered BBB permeability [88]

Based on these factors, here is a brief comparison between the two routes of administration: Bioavailability: Overall, researchers should expect significantly higher bioavailability with PT-141 injections compared to PT-141 nasal spray

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