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Mafra D, Borges N, Alvarenga L, Esgalhado M, Cardozo L, Lindholm B

The fibrosis and vasoconstriction that accompany this aberrant vascular remodeling response raise the pressure in the pulmonary arteries, which ultimately leads to early death

During the malignant progression of tumors, a variety of signaling pathways are activated to participate in the proliferation, migration, angiogenesis and metabolic remodeling of tumor cells, among which IGFs play important regulatory roles (76)

Conclusion: OGT and Ezh2 are two druggable targets that co-regulate cancer-related gene expression in transformed liver cells

2012;7:e33057

The sample was small (10 subjects per group)