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Ischemia-induced programmed cell death in astrocytes

Normally, about 80% of Hcy is bound to plasma proteins such as albumin by disulfide bonds, and the rest of Hcy is mostly bound to thiols in the form of cystine or other forms, while only a small portion is free

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The OS did not differ between treatment groups neither in the overall patient population (median OS 8.8 months vs 6.9 months in the olaparib and placebo group, respectively, HR=0.79, 95%CI 0.63-1.00, p=0.026) nor in the ATM-negative population (12.0 months vs 10.0 months, HR=0.73, p=0.25) (77, 79)

Hcy, homocysteine