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The basal-like subtype, commonly referred to as triple negative, lacks ER, PR, and HER2 expression, accounts for approximately 15% of breast cancers, and is associated with poor prognosis (137139) HER2-enriched tumours display high HER2 expression, increased proliferation, and are typically ER- and PR-negative ( Figure 5 ) (135, 140, 141)

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For the varying number of subjects, we are not sure where the reviewer is seeing this