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29, 30 This layering of antioxidants provides broad spectrum coverage across multiple oxidative pathways, providing greater protection

This paves the way for developing precision anti-inflammatory therapies and, coupled with advanced delivery systems like nanocarriers for targeted brain delivery, holds significant potential for providing causative treatment for tinnitus patients identified as belonging to an inflammatory subtype based on their specific biomolecular profile (He S

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We thank Catherine Sampson for her assistance with the mouse blood collection and epididymis fat-pad isolation procedures

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Taken together, the present findings suggest CD38 as an immunometabolic checkpoint that could be adopted as a pre-symptomatic biomarker for early diagnosis of AD, and might also be therapeutically targeted alone or in combination with other immunotherapies for disease modification