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Finally, artipilin C (ARC) contained in Brazilian Green Propolis ameliorates UC and colitis-associated colorectal cancer by targeting p21-activated kinase 1 (PAK1) [332]

Present evidence suggests that chemo preventive agents may be used in cancer treatment (Tallberg et al

10.1016/j.carbpol.2019.02.018 16 BazyarH.GholinezhadH.MoradiL.SalehiP.AbadiF.RavanbakhshM.et al (2019)

Liu X, Ren B, Ren J, Gu M, You L, Zhao Y

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cup1 and ppr4 genetic mutants and epimutants exhibited increased efflux rates, consistent with higher intracellular ROS triggering Pap1 nuclear retention where it drives increased expression of COSG genes including efflux pumps and consequently resistance to external insults such as caffeine and azole-based antifungals (model, Fig