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Additionally, pinocembrin has been shown to restore cognitive function and reduce neuronal apoptosis and hippocampal inflammation in vivo, mainly by inhibiting NLRP3 inflammasome formation, reducing microglial infiltration, and enhancing BNIP3-mediated mitophagy through the JNK-ERK signaling pathway [175]

Clin Lab 66(8):1549

For example, in a rat model of CHI induced by permanent bilateral common carotid artery occlusion (2VO), GA significantly restored spatial memory, increased time spent in the target quadrant, and improved memory consolidation (Sarkaki et al., 2014)

Over time, persistent follicular inflammation contributes to progressive miniaturization and, in its most severe expression, irreversible fibrosis of the follicular unit

The Human Gut Microbiome in Early-Onset Type 1 Diabetes From the TEDDY Study

Ferroptosis is an iron-dependent lipid peroxidation-mediated cell death