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This amplified warming of cold extremes over North America is found in climate model projections 17 and observations show a reduction in cold extremes over recent decades over North America 18,19 , including amplified warming of extreme cold relative to the mean in observations up until 2014 16

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A typical example is that arginylglycylaspartic acid (RGD)-modified MSNs can selectively bind integrin 3 receptor and thus be applied to target tumor neovascularization

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