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During metabolic stresses such as increased oxidative phosphorylation or changes in cytoplasmic homeostasis that induce ER stress, the UPS will be compromised, which would most likely result in a reduction in BACE1 degradation by the UPS and lysosomes

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"A Comparative Analysis of S-Acetylglutathione and Liposomal Glutathione Bioavailability." BenchChem.

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