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Oxidative stress through the generation of reactive oxygen species (ROS), mitochondrial DNA mutations (Abu-Amero et al., 2006), and defective mitochondrial quality control mechanisms through IOP-induced fission and cristae depletion (Ju et al., 2008) represent mitochondrial dysfunction that has been implicated in glaucoma (Zhang et al., 2023)

Legchenko E, Chouvarine P, Borchert P, Fernandez-Gonzalez A, Snay E, Meier M, et al

Also, genetic interactions between minor alleles in the selenoprotein S gene ( SELENOS ) and the nuclear factor erythroid 2-related factor 2 gene ( NFE2L2 ) increase chronic thyroiditis incidences (105)

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Notably, despite the growing number of immunotherapies targeting p53, these approaches are still in the early stages of development