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This molecule impacts B lymphocytes, T lymphocytes, natural killer cells, macrophages, dendritic cells, and myeloid-derived suppressor cells, leading to immunosuppression that favours tumour growth ( Figure 7 ) ( Figure 7 KRAS (Kirsten rat sarcoma virus) Mutations KRAS (Kirsten rat sarcoma virus) is an oncogene that is mutated in about 25% of all cancers, but it only recently became a promising therapeutic target for anti-cancer therapy because of significant scientific breakthroughs ( Figure 8 ) ( KRAS -mutant cancers have been difficult to treat via drugs due to the small size of K-Ras and its lack of binding sites ( KRAS gene lock K-Ras into the on state, resulting in uncontrolled cell growth that leads to cancer

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Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH et al

2021 May;18(5S):S139-S152