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The nephrotoxic mechanisms of IS have been characterized primarily through in vitro and animal models, with limited validation in human DKD

K.KraftK.StckerM.et al (2022)

Vitamins are known to play important roles in the process of skin pigmentation

Therefore, besides its potent anti-oxidative stress effects, bilirubin may also attenuate inflammation in osteoarthritis (OA) by inhibiting the NF-B pathway (99), and some studies have suggested that osteoarthritis may promote the development of cancer, so bilirubin may serve to decrease the cancer development risk in this way (100)