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10.1016/j.cmet.2014.11.003 Cell Metab

Under hypoxic conditions, HIF-1 regulates aldehyde dehydrogenase 1 family member A3 (ALDH1A3) upregulation in HGSC cells, leading to increased H3K27ac modification levels in the PITX1 promoter region, which directly reduces cell sensitivity to cisplatin [136]

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For behavioral analysis with post-adding chemicals, assay plates were prepared by first seeding 12.5 L indicated bacterial cultures onto NGM agar for growth, as described in the section Screen for C