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Energy minimization was conducted with the steepest descent method (maximum force tolerance of 1000 kJmolnm, step size 0.01 nm), followed by 100 ps NVT equilibration (0310.15 K) and 100 ps NPT equilibration (310.15 K, 1 bar) using the Berendsen barostat

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These results support a model in which residues P88 and P91 mediate activation via the arr1-N site, while F75, N122, and I314 are essential for activation via the arr1-CC site

(2012): adding vitamin E early in the course of ALS in an SOD1 model (at 30 days) to CEF and minocycline (both started at 90 days) improves survival significantly

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