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Schematic illustration of protein cleavage by TEV Protease Enzymatic Mechanism of TEV Protease Since TEV protease is a cysteine protease its activity is not affected by serine protease inhibitors, although the enzymatic mechanism reminds of the catalytic triade found in serine proteases

275,276 SGLT-2Is reduce MACE (primarily by reducing cardiovascular death), 277 hospitalizations due to heart failure, 278 and CKD progression 278 (including significant reductions in albuminuria and delayed eGFR decline) in various populations, irrespective of baseline glycemic status

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[100] Transcript, The Rachel Maddow Show, MSNBC, December 22, 2015