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The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

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For the synthesis of ubiquitin conjugates (C19)x(Ub) and (C19scr)x(Ub), the native chemical ligation (NCL), desulfurization and deAcm were used

Cancer Discov (2025)

This form of glutathione has shown higher bioavailability and greater efficacy in raising cellular glutathione levels compared to traditional oral supplements

Activation of G protein-coupled estrogen receptor 1 at the onset of reperfusion protects the myocardium from I/R injury by decreasing mitophagy through the PINK1/Parkin pathway [104]