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The same mitogenic activity is the basis of long-term cancer concern, because IGF-1 signaling is one of the more well-documented growth pathways studied in tumor biology

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Notably, the algorithms that we propose here are similar to the approach used in the recent BATCH study in which a PCT-guided algorithm for antibiotic duration was non-inferior to usual care without PCT among all patients, but did safely reduce the median antibiotic duration in the subset with adherence to the PCT-guided algorithms