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5.2.3 Bottlenecks and opportunities in clinical translation While ferroptosis-targeted strategies show promise in OA models, the translation to clinical settings remains hindered by key limitations in safety, efficacy, and delivery

observed in their study that higher consumption of energy, protein, saturated fats, and sodium was associated with a higher risk of colon cancer, while, on the contrary, micronutrients such as vitamin E and caffeine intake were inversely related to colon cancer prevalence [179]

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Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

Furthermore, the combined treatment reduced -catenin nuclear localization, cyclin D1 expression, and cellular proliferation (55)