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Int J Pept Res Ther 28:87 Veldhuizen EJ, Schneider VA, Agustiandari H, van Dijk A, Tjeerdsma-van Bokhoven JL, Bikker FJ, Haagsman HP (2014) Antimicrobial and immunomodulatory activities of PR-39 derived peptides

Reduces Fat Cell Size and Promotes Lipolysis Research indicates that NNMT inhibition leads to shrinkage of white adipose tissue and a shift toward fat oxidation , making the body more efficient at burning stored fat for energy

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In an environment with elevated CD38 activity, such as seen in SSc lesional skin, administering NAD + precursors or enhancing NAD + synthesis will have limited effect on increasing NAD + levels, as elevated CD38 continues to degrade NAD +