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IgM, considered an ancient antiviral weapon, exists in all vertebrates (220)

Cyclic vomiting syndrome phases Inter-episodic phase (feeling generally well) Prodrome (early symptoms without vomiting) Vomiting phase (nausea, vomiting and retching, abdominal pain) Recovery (slowly regain energy, hydrating and eating) This is important to understand as medications can be administered at the first sign of symptoms during the prodrome phase to stop or reduce symptoms of CVS from progressing to a full-blown episode

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The trend appears to correlate with evolution of sex in these organisms, with only the apicomplexans which lack the key enzymes in the TS pathway exhibiting sexual stages in their life cycle

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