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doi: 10.1016/j.molmet.2020.101131 24 BoroughsLKDeBerardinisRJ

BaP is a carcinogen and can cause epigenetic changes such as DNA methylation and histone acetylation [15], in addition, BaP can affect DNA methylation and demethylation, the most important part of epigenetics, by influencing DNMTs and thus DNA methylation [77, 152]

While many side effects are manageable, certain symptoms require prompt medical evaluation: Severe or persistent abdominal pain Signs of pancreatitis, such as nausea, vomiting, and severe stomach pain Symptoms of hypoglycemia, especially if frequent or severe Allergic reactions, including rash, swelling, or difficulty breathing Persistent diarrhea or dehydration If you experience any of these, seek medical advice immediately

10.2174/092986712800167392 52 PantziarkaP.SukhatmeV.CrispinoS.BoucheG.MeheusL.SukhatmeV

Skin Concern: Signs of skin aging

Traditionally, greater than three standard deviations above the mean is considered elevated, but levels less elevated than this will often decline in patients supplemented with cobalamin or folate, perhaps indicating a relative deficiency of these vitamins