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In Alzheimers patients develop beta-amyloid plaques as a response to the chronic inflammatory process

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It stabilizes the active conformation of the receptor, allowing for the recruitment of the co-activator PGC-1

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Briefly, 100 L of cell-free supernatant from each well of a 24-well plate were transferred to a 96-well plate and 20 L of iodonitrotetrazolium chloride (4 mg/mL, Sigma-Aldrich) were added to each well