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Among the available strategies, interventions aimed at mtDNA mutationinduced mitochondrial dysfunction are the most thoroughly investigated and show the greatest progress toward clinical translation

The H 2 O 2 concentration drives the redox balance in the cell from GSH toward GSSG (see Figure 1) and the increased concentrations of H 2 O 2 and GSSG can modulate many enzymes in one-carbon metabolism (see Section E)