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FIGURE 1 FIGURE 2 Individual-centric spheroids did not show cell over proliferation in long-term cell culture conditions The use of immortalized cell lines such as HepG2 or Huh7 to generate spheroids for DILI assessment often suffers from excessive uncontrolled cell proliferation resulting in enlarged spheroids with a necrotic core that can alter drug penetration and drug responses and thereby reducing the physiological relevance and predictive accuracy of the model

474 Amino acid deprivation therapy utilizes enzymes secreted by microorganisms in anticancer treatments by exploiting the metabolic differences between cancerous and normal cells

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Postmenopausal women who carried the MTHFR C677T variant were found to be at a 2 to 3-fold increased risk of depression.[ref] I do want to point out that not all studies agree, and some researchers find that the MTHFR C677T variant has little to no impact on depression risk