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Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function

J., Kadiiska, M

Wernerman J Article: JOURNAL OF INHERITED METABOLIC DISEASE

While we present results for all studies, we also present treatment time and individual outcome analyses, which may be more informative for specific use cases