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Where as known inhibitor pyrazole did inhibit ADH activity in the same experiment with an IC50 consistent with previous reports (Supplementary Figure S8)

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The size of these dense granules was larger (in the range of a few thousand angstroms) than previously reported for mitochondrial electron-dense clusters in mineralizing osteoid (ranging from 400 to 1000 angstroms) (Landis et al., 1977) The authors (Omelon et al., 2009) put together a hypothesis that apatite mineral dissolution in the osteoclast resorption zone increases the concentrations of free P i and Ca 2+

Maes M, Jirakran K, Semeo LO, Michelin AP, Matsumoto AK, Brinholi FF, Barbosa DS, Tivirachaisakul C, Almulla AF, Stoyanov D, Zhang Y