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Collectively, these results indicate that hippocampal astrocytic Hb, rather than CA1 pyramidal neuronal Hb, is necessary for the antioxidative action of KDS12025, effectively alleviating astrogliosis and hippocampus-dependent memory impairment in an animal model of AD

During metabolic stresses such as increased oxidative phosphorylation or changes in cytoplasmic homeostasis that induce ER stress, the UPS will be compromised, which would most likely result in a reduction in BACE1 degradation by the UPS and lysosomes

LBE supplementation led to an increase in indole derivatives, metabolites produced by the GI microbiota from dietary tryptophan and known to have immunological significance, as observed in untargeted metabolomics

Glutathione works by protect energy-producing factories inside cells called mitochondria. Antioxidants are molecules that inhibit other molecules from going through oxidation, a chemical reaction that produces toxins called free radicals

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Antioxidants in the fight against atherosclerosis: is this a dead end