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doi: 10.3389/fnut.2022.982228 Received 30 June 2022 Accepted 28 July 2022 Published 15 August 2022 Volume 9 - 2022 Edited by Daniel Cozzolino, University of Queensland, Australia Reviewed by Qun Huang, Guizhou Medical University, China

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This may play a role in maintaining proper spinal function

10.3390/ijms22062963 243 SaalJ

10.1016/j.cell.2013.12.010 220 YangW

Current evidence supports esculetin as a promising multi-target enzyme inhibitor against acetylcholinesterase (AChE), which breaks down acetylcholine (IC = 6.13 M), as well as on butyrylcholinesterase (BChE), involved in neurotransmitter breakdown (IC = 8.66 M), and on -site amyloid precursor protein cleaving enzyme (BACE1), critical for producing amyloid-beta (IC = 7.67 M) (Ali et al