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Current Evidence Level Stating the evidence tier precisely, without softening: Weighing the positive and negative studies The positive human evidence is real but structurally weak, and the weakness is specific: nearly all of it comes from a single investigator group

2021;11(12):e048575

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While GHK-Cu, a peptide that our bodies make, is used topically in skin cream in an attempt to reduce fine lines, it is not considered safe to inject due the lack of scientific research and the risks of triggering a potentially dangerous immune response