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In prolonged abdominal sepsis patients ( n = 14), muscle glutamine concentration was identified as the single most reliable factor that effectively discriminated survivors from non-survivors ( de novo GS-mediated glutamine synthesis

aeruginosa , the MexR repressor senses oxidative stress (two Cys residues form disulfides), dissociates from the mexAB-oprM promoter, and derepresses efflux under peroxide stress

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This conversion requires the enzyme glutamatecysteine ligase (GCL, glutamate-cysteine synthase)

However, chronic illness can severely deplete vital resources like glutathioneoften referred to as the body's master antioxidantleaving cells vulnerable to ongoing damage

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