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In moderate-to-severe active UC, ustekinumab is recommended in adults who have not responded or have contraindications to anti-TNF therapy[99]

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TRPPs have only one specific structural feature, an extensive loop called polycystin, which projects to the cytoplasm and is found in the middle of S1-S2

Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray

The advantage of using partial identification methods is that, unlike the ITT measure, they provide the causal effect of mandating an intervention or program and, unlike the LATE, they provide the causal effect for the entire population of interest

Burning or stinging that intensifies with continued use, rather than diminishing, indicates genuine irritation rather than adjustment