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Intravenous, intramuscular, and nebulized routes achieve higher systemic levels but require clinical administration and are reserved for specific medical indications

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NLRP3 activation promotes the maturation of pro-inflammatory cytokines, such as IL-1 and IL-18 and contributes to pyroptotic cell death a relatively rapid inflammatory form of cell death

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Maintaining host cell integrity is crucial for preventing bacterial dissemination and facilitating immune cell migration to infection sites