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Ogasawara N, Goto H, Yamada Y, et al

Administration results in competitive antagonism at the motor end-plate, which decreases both the miniature end-plate potential (MEPP) and the muscle's response to exogenously applied acetylcholine

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This process may subsequently upregulate ER expression and enhance its stability by activating stress-related signaling pathways [Citation90]

10.1101/gad.334219.119 Genes Dev

Time zone changes may affect the weekly dosing schedule, and patients should plan how to maintain consistent seven-day intervals between doses while accommodating their travel schedule