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Vincristine, a chemotherapeutic agent, is known to cause neurotoxicity by decreasing levels of the antioxidant protein Nrf2 and its downstream targets HO-1 and NQO1

In several experimental models of autoimmune diseases (including thyroiditis), EVOO components, oleic acid, hydroxytyrosol, oleuropein, and oleocanthal, have proven effective in counteracting inflammatory and oxidative imbalances, suggesting their efficacy in preventing autoimmune diseases [62, 136, 137]

Rapid mechanisms of glucocorticoid signaling in the Leydig cell

For established cognitive support, the evidence-based options include aerobic exercise (strong evidence for cognitive benefits, especially executive function and processing speed), sleep optimization (critical for cognitive function), Mediterranean diet (modest evidence for cognitive protection over years), treating sleep apnea (significant cognitive improvements when this condition is addressed), treating depression (major cognitive effects when present), donepezil and other approved Alzheimer drugs (modest evidence-based effects in actual Alzheimer disease), and stimulants (well-established for ADHD)

6 Challenges and best practices While integrating phytoremediation research into STEM education holds great promise, implementation is not without significant obstacles

doi: 10.1016/j.psychres.2018.05.059 203 BazinetRPLayS