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These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005

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Its structure incorporates specific amino acid substitutions to enhance solubility and prevent fibril formation, along with the addition of a C18 fatty diacid moiety via a linker