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Oral administration of luteolin (10 mg/kg) in both the early and delayed luteolin treatment groups effectively inhibited the infiltration of neutrophils into BALF and increased TNF-R and IL-6 levels in C57BL/6 mice intubated with BLM

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However, once cancer is established, whether AMPK promotes or suppresses tumorigenesis depends on the cancer type and contextual conditions [342]

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Another in vitro study also supported this view, but a diverse mechanistic interpretation suggested that after treatment with KRAS (G12C) inhibitors, some cancer cells were in a stationary state with low KRAS activity, while others were equipped to resume proliferation due to the synthesis of new KRAS (G12C) 177,232