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The continuous hyperglycemia can induce target organ damage (TOD) by increasing the risk of panvascular disease, including microvascular disease (such as diabetic retinopathy, nephropathy and neuropathy), and atherosclerotic macrovascular disease (cardiovascular, cerebrovascular, and other peripheral vascular diseases)

As noted, -syn pathology in PD might start in the gut (possibly triggered by a pathogen or toxin) and spread via the vagus nerve

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To ensure the robustness of findings, sensitivity analyses were performed by excluding potentially influential observations identified through Cooks distance