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Environment dictates dependence on mitochondrial complex I for NAD + and aspartate production and determines cancer cell sensitivity to metformin

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Therefore, the strategic targeting of MDSCs to convert GBM from a "cold" tumor, refractory to immune response, to a "hot" tumor that responds favorably to immunotherapy holds significant therapeutic promise (Fig

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To exclude the effects of these metabolic intermediates on pyroptosis, we then pretreated hepatocytes with L-methionine (L-Met) or tetrahydrofolic acid (THF) and found neither can block GSDME-mediated pyroptosis (Supplementary Fig

Both authors contributed to the article and approved the submitted version