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Frey, S

Fisher MA

R The clinical approach is straightforward: sodium butyrate solution (typically 80-100 mM in normal saline) is instilled as a retention enema into the excluded bowel segment daily or twice daily

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PYC is able to enhance synaptic plasticity by promoting the expression of brain-derived neurotrophic factor (BDNF) (Kebir and Joober, 2011), an important neurotrophic factor that promotes neuronal growth, differentiation and synapse formation

Differentiated cells express key hepatocyte markersincluding albumin, tyrosine aminotransferase (TAT), and cytokeratin-18 (CK18)at both the mRNA and protein levels and exhibit essential hepatocyte functions, such as albumin secretion, glycogen storage, and cytochrome P450 7A1 expression, thereby effectively mimicking the metabolic and detoxification functions of mature hepatocytes (Malik et al., 2018)