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By influencing NNMT-associated pathways, it serves as a valuable tool in in vitro studies examining metabolic regulation, mitochondrial function, and potential applications in obesity and age-related research contexts

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Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase

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The rise in intracellular calcium triggers the activation of calcium/calmodulin dependent protein kinase II (CaMKII), which releases large amounts of calcium from the sarcoplasmic reticulum calcium pool into the cytoplasm, causing calcium overload