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Functional deficiency of astrocytic glutamate clearance and K + buffering is the primary cause of neuronal damage in neurodegenerative diseases, most notably in amyotrophic lateral sclerosis (ALS) and Huntingtons disease (HD) 148,149,150,151,152,153 , whereas functional asthenia of astrocytes may exacerbate -amyloid pathology in the context of Alzheimers disease (AD) 154

The search involved Pubmed and OVID Medline with the inclusion of a broad variety of terms: Zn or nervous system, brain, neurodevelopment, in combination with the individual search terms for each section of this review such as: glucose and Zn, autoregulation, carbonic anhydrase, nitric oxide synthase, etc

Concretely, the beneficial commensal genera decreased, including FP (226, 227), Clostridiaceae , Rikenella , Bacteroides , Prevotella , Roseburia , Pseudobutyrivibrio , Escherichia/Shigella , and Raecalibacterium (228), whereas the pathobiont genera rose, including Lactobacillus (229), Ruminococcus , Akkermansia , Bifidobacterium , Fusobacterium , Erwinia , and Streptococcus (230, 231)

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