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An additional constraint could arise from the fact that while ferrostatin-1 has also previously shown efficacy in inhibiting ferroptosis in other human organoid models, such as bronchial [56] and gut crypt organoids [57], its utility is hindered by its solubility issues

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Glutathione Peroxidases: Glutathione peroxidases are involved in reducing hydrogen peroxide and organic peroxides

CD44-ICD also drove the expression of three oxidative glycolysis-related vital genes (ALDOC, 3-Phosphoinositide-dependent kinase 1 (PDK1) and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)), maintaining the metabolic needs for cancer cell survival preferentially through oxidative glycolysis rather than citric acid cycle even in the condition of adequate oxygen supply [78]

In mycotoxin-induced liver injury, JNK has been reported to both promote and limit damage