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2.3 The Role of Ferroptosis in Heart Failure HF is not an independent disease, but the final stage of the development in most primary Cardiovascular Diseases, contributing to high morbidity and mortality worldwide and a huge social and economic burden on the healthcare system (Wu et al., 2021b)

Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension

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Preclinical proof of concept was obtained from a humanized mouse model of pemphigus vulgaris, in which autoimmune B cells target desmogleins causing skin and other mucous membranes to blister

doi: 10.1007/s12011-022-03247-x 80 PascaleA.MarchesiN.MarelliC.CoppolaA.LuziL.GovoniS.et al