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Interestingly, the activity of methylating enzymes such as the S -adenosylmethionine-dependent protein arginine methyltransferase (type I) 103 responsible for the ADMA synthesis or the activity of ADMA hydrolyzing enzymes such as dimethylarginine dimethylaminohydrolase 102 are redox sensitive

10.1523/jneurosci.20-23-08812.2000 129 VidyasagarT

Nairz et al., 2017)

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Several days after the start of treatment, repeat testing showed improving bone marrow recovery, with an increase in reticulocyte count and normalization of lactate dehydrogenase