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As compared with non-metastatic set up, LOX expression in human HCC cells was significantly enhanced in metastatic set up after interaction with polarized macrophages in vitro

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(2021a, b) in diabetic db/db mice and high glucose-induced HK-2 cells, AC could improve early renal damage induced by DM through regulating TGF-/Smad signaling pathway, which is implicated in regulating renal fibrosis in chronic kidney disease (Wang et al

When cells respond to chronic hyperglycemia, the expression of NOX enzymes is upregulated, activating angiotensin II type 1 receptor (AT1R) and increasing superoxide production [152153]

doi: 10.1038/nrg2348 141 WuY.GongW.WangY.YongT.YangF.LiuW.et al

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