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3.2 Destruction of periodontal soft tissues The integrity and function of PDLFs, essential for softtissue homeostasis, are compromised by ferroptosis through a twofold assault on collagen: synthesis is reduced because PDLF viability and activity are impaired, while degradation is accelerated by ferroptosisassociated ROS and proinflammatory mediators (50)

Extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1beta expression in human monocyte-derived macrophages

Probiotics may help manage obesity in children and adolescents

Although current research in this field is limited, these findings collectively suggest that targeted induction of microbial ferroptosis could attenuate ALD-driving pathobionts, thereby providing a novel therapeutic perspective for ALD management

[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Misaka S., Yatabe J., Mller F., Takano K., Kawabe K., Glaeser H., Yatabe M.S., Onoue S., Werba J.P., Watanabe H., et al

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